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Citations to this article

Hepatocyte SREBP signaling mediates clock communication within the liver
Dongyin Guan, … , Cholsoon Jang, Mitchell A. Lazar
Dongyin Guan, … , Cholsoon Jang, Mitchell A. Lazar
Published April 17, 2023
Citation Information: J Clin Invest. 2023;133(8):e163018. https://doi.org/10.1172/JCI163018.
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Research Article Hepatology Metabolism Article has an altmetric score of 10

Hepatocyte SREBP signaling mediates clock communication within the liver

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Abstract

Rhythmic intraorgan communication coordinates environmental signals and the cell-intrinsic clock to maintain organ homeostasis. Hepatocyte-specific KO of core components of the molecular clock Rev-erbα and -β (Reverb-hDKO) alters cholesterol and lipid metabolism in hepatocytes as well as rhythmic gene expression in nonparenchymal cells (NPCs) of the liver. Here, we report that in fatty liver caused by diet-induced obesity (DIO), hepatocyte SREBP cleavage–activating protein (SCAP) was required for Reverb-hDKO–induced diurnal rhythmic remodeling and epigenomic reprogramming in liver macrophages (LMs). Integrative analyses of isolated hepatocytes and LMs revealed that SCAP-dependent lipidomic changes in REV-ERB–depleted hepatocytes led to the enhancement of LM metabolic rhythms. Hepatocytic loss of REV-ERBα and β (REV-ERBs) also attenuated LM rhythms via SCAP-independent polypeptide secretion. These results shed light on the signaling mechanisms by which hepatocytes regulate diurnal rhythms in NPCs in fatty liver disease caused by DIO.

Authors

Dongyin Guan, Hosung Bae, Dishu Zhou, Ying Chen, Chunjie Jiang, Cam Mong La, Yang Xiao, Kun Zhu, Wenxiang Hu, Trang Minh Trinh, Panpan Liu, Ying Xiong, Bishuang Cai, Cholsoon Jang, Mitchell A. Lazar

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Total citations by year

Year: 2025 2024 2023 Total
Citations: 2 3 4 9
Citation information
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Citations to this article (9)

Title and authors Publication Year
Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling
Régnier M, Polizzi A, Fougeray T, Fougerat A, Perrier P, Anderson K, Lippi Y, Smati S, Lukowicz C, Lasserre F, Fouche E, Huillet M, Rives C, Tramunt B, Naylies C, Garcia G, Rousseau-Bacquié E, Bertrand-Michel J, Canlet C, Chevolleau-Mege S, Debrauwer L, Heymes C, Burcelin R, Levade T, Gourdy P, Wahli W, Blum Y, Gamet-Payrastre L, Ellero-Simatos S, Guillermet-Guibert J, Hawkins P, Stephens L, Postic C, Montagner A, Loiseau N, Guillou H
PLOS Biology 2025
Circadian clock communication during homeostasis and ageing.
Mortimer T, Smith JG, Muñoz-Cánoves P, Benitah SA
Nature reviews. Molecular cell biology 2025
The role of circadian clock in regulating cell functions: implications for diseases.
Lin Y, He L, Cai Y, Wang X, Wang S, Li F
2024
Improvement of MASLD and MASH by suppression of hepatic N-acetyltransferase 10.
Yang Y, Lu J, Liu Y, Zhang N, Luo Y, Ma M, Dong Z, Zhang S, Zheng MH, Ruan CC, Wan X, Hu C, Lu Y, Ma X, Zhou B
Molecular metabolism 2024
Liver as a nexus of daily metabolic cross talk.
Litwin C, Koronowski KB
International review of cell and molecular biology 2024
Circadian mechanisms in adipose tissue bioenergetics and plasticity.
Hepler C, Bass J
Genes & development 2023
E-box binding transcription factors in cancer.
Pan Y, van der Watt PJ, Kay SA
Frontiers in Oncology 2023
Hepatic TRPC3 loss contributes to chronic alcohol consumption-induced hepatic steatosis and liver injury in mice
Ding Q, Guo R, Hao L, Song Q, Fu A, Lai S, Xu T, Zhuge H, Chang K, Chen Y, Wei H, Ren D, Sun Z, Song Z, Dou X, Li S
Life Metabolism 2023
Circadian rhythms and inflammatory diseases of the liver and gut
Ferrell JM
Liver Research 2023

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Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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