Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma
Apeng Chen, … , Carlos J. Camacho, Baoli Hu
Apeng Chen, … , Carlos J. Camacho, Baoli Hu
Published July 6, 2021
Citation Information: J Clin Invest. 2021;131(16):e147552. https://doi.org/10.1172/JCI147552.
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Research Article Oncology

Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma

Abstract

Authors

Apeng Chen, Yinan Jiang, Zhengwei Li, Lingxiang Wu, Ulises Santiago, Han Zou, Chunhui Cai, Vaibhav Sharma, Yongchang Guan, Lauren H. McCarl, Jie Ma, Yijen L. Wu, Joshua Michel, Yi Shi, Liza Konnikova, Nduka M. Amankulor, Pascal O. Zinn, Gary Kohanbash, Sameer Agnihotri, Songjian Lu, Xinghua Lu, Dandan Sun, George K. Gittes, Qianghu Wang, Xiangwei Xiao, Dean Yimlamai, Ian F. Pollack, Carlos J. Camacho, Baoli Hu

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Figure 10

The levels of CHI3L1, LGALS3, and LGALS3BP mRNA expression predict anti–PD-1 response in GBM patients.

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The levels of CHI3L1, LGALS3, and LGALS3BP mRNA expression predict anti–...
(A) Histogram analysis of the distribution of anti–PD-1 treatment responders and nonresponders in GBM patients following anti–PD-1 treatment from a previous data set (41). The n represents the number of patients characterized with indicated gene expression. (B) Schematic drawing indicates that glioma cell–intrinsic CHI3L1 binding with Gal3 forms a protein-binding complex modulating the TAM-mediated immune microenvironment for tumor progression, which is negatively regulated by Gal3BP or GMP.