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Research Article Free access | 10.1172/JCI119198

Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat.

V Kren, M Pravenec, S Lu, D Krenova, J M Wang, N Wang, T Merriouns, A Wong, E St Lezin, D Lau, C Szpirer, J Szpirer, and T W Kurtz

Institute of Biology, First Medical Faculty, Charles University, Prague, Czech Republic.

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Institute of Biology, First Medical Faculty, Charles University, Prague, Czech Republic.

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Institute of Biology, First Medical Faculty, Charles University, Prague, Czech Republic.

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Institute of Biology, First Medical Faculty, Charles University, Prague, Czech Republic.

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Institute of Biology, First Medical Faculty, Charles University, Prague, Czech Republic.

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Institute of Biology, First Medical Faculty, Charles University, Prague, Czech Republic.

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Institute of Biology, First Medical Faculty, Charles University, Prague, Czech Republic.

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Institute of Biology, First Medical Faculty, Charles University, Prague, Czech Republic.

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Institute of Biology, First Medical Faculty, Charles University, Prague, Czech Republic.

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Institute of Biology, First Medical Faculty, Charles University, Prague, Czech Republic.

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Institute of Biology, First Medical Faculty, Charles University, Prague, Czech Republic.

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Institute of Biology, First Medical Faculty, Charles University, Prague, Czech Republic.

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Institute of Biology, First Medical Faculty, Charles University, Prague, Czech Republic.

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Published February 15, 1997 - More info

Published in Volume 99, Issue 4 on February 15, 1997
J Clin Invest. 1997;99(4):577–581. https://doi.org/10.1172/JCI119198.
© 1997 The American Society for Clinical Investigation
Published February 15, 1997 - Version history
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Abstract

The spontaneously hypertensive rat (SHR) is the most widely studied animal model of essential hypertension. Despite > 30 yr of research, the primary genetic lesions responsible for hypertension in the SHR remain undefined. In this report, we describe the construction and hemodynamic characterization of a congenic strain of SHR (SHR-Lx) that carries a defined segment of chromosome 8 from a normotensive strain of Brown-Norway rats (BN-Lx strain). Transfer of this segment of chromosome 8 from the BN-Lx strain onto the SHR background resulted in substantial reductions in systolic and diastolic blood pressure and cardiac mass. Linkage and comparative mapping studies indicate that the transferred chromosome segment contains a number of candidate genes for hypertension, including genes encoding a brain dopamine receptor and a renal epithelial potassium channel. These findings demonstrate that BP regulatory gene(s) exist within the differential chromosome segment trapped in the SHR-Lx congenic strain and that this region of chromosome 8 plays a major role in the hypertension of SHR vs. BN-Lx rats.

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