Advertisement

Research Article Free access | 10.1172/JCI118990

Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome.

K Konstantinov, A von Mikecz, D Buchwald, J Jones, L Gerace, and E M Tan

Autoimmune Disease Center and Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Find articles by Konstantinov, K. in: JCI | PubMed | Google Scholar

Autoimmune Disease Center and Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Find articles by von Mikecz, A. in: JCI | PubMed | Google Scholar

Autoimmune Disease Center and Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Find articles by Buchwald, D. in: JCI | PubMed | Google Scholar

Autoimmune Disease Center and Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Find articles by Jones, J. in: JCI | PubMed | Google Scholar

Autoimmune Disease Center and Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Find articles by Gerace, L. in: JCI | PubMed | Google Scholar

Autoimmune Disease Center and Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Find articles by Tan, E. in: JCI | PubMed | Google Scholar

Published October 15, 1996 - More info

Published in Volume 98, Issue 8 on October 15, 1996
J Clin Invest. 1996;98(8):1888–1896. https://doi.org/10.1172/JCI118990.
© 1996 The American Society for Clinical Investigation
Published October 15, 1996 - Version history
View PDF
Abstract

We have identified and partially characterized the autoantibodies in sera of 60 patients with chronic fatigue syndrome. Approximately 52% of the sera were found to react with nuclear envelope antigens. The combination of nuclear rim staining observed in immunofluorescence microscopy and immunoblot analysis of highly purified nuclear envelope proteins provided initial characterization of these autoantibodies. Further characterization showed that some sera immunoprecipitated the in vitro transcription and translation product of a human cDNA clone encoding the nuclear envelope protein lamin B1. The autoantibodies were of the IgG isotype. The occurrence of autoantibodies to a conserved intracellular protein like lamin B1 provides new laboratory evidence for an autoimmune component in chronic fatigue syndrome.

Version history
  • Version 1 (October 15, 1996): No description
Advertisement
Advertisement