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Research Article Free access | 10.1172/JCI111754

Human B lymphoma cell line producing B cell growth factor.

J L Ambrus Jr and A S Fauci

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Published February 1, 1985 - More info

Published in Volume 75, Issue 2 on February 1, 1985
J Clin Invest. 1985;75(2):732–739. https://doi.org/10.1172/JCI111754.
© 1985 The American Society for Clinical Investigation
Published February 1, 1985 - Version history
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Abstract

Namalva, a human B cell lymphoma line, produced a factor with a molecular weight of approximately 60,000 which enhanced the proliferation of normal activated human B lymphocytes. The factor also enhanced the proliferation of certain B cell lines. It can be distinguished physiologically and biochemically from other lymphokines known to enhance B cell proliferation, namely, interleukin (IL) 1, IL 2, and interferon. The production of B cell growth factor by B cell tumor lines may contribute to their ability to grow autonomously and may reflect an important component of the neoplastic potential of the cell. B cell growth factor produced by tumors may also affect normal cells in vivo.

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