Decrease in microviscosity and cholesterol content of rat liver plasma membranes after chronic ethanol feeding.

S Yamada; C S Lieber

doi:10.1172/JCI111656

Published December 1, 1984 - More info

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Abstract

This investigation was performed to determine whether chronic ethanol feeding alters the lipid composition or the fluidity of liver plasma membranes. Male Sprague-Dawley rats were pair-fed nutritionally adequate liquid diets containing ethanol as 36% of energy or an isocaloric amount of carbohydrate for 4-5 wk. Contrasting with other membranes, chronic ethanol feeding resulted in an increase in hepatic plasma membrane fluidity as assessed by fluorescence anisotropy. This alteration was associated with a decrease in plasma membrane cholesterol content.