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Chemokine-receptor activation by env determines the mechanism of death in HIV-infected and uninfected T lymphocytes
Stacey R. Vlahakis, … , Ronald G. Collman, Carlos V. Paya
Stacey R. Vlahakis, … , Ronald G. Collman, Carlos V. Paya
Published January 15, 2001
Citation Information: J Clin Invest. 2001;107(2):207-215. https://doi.org/10.1172/JCI11109.
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Article

Chemokine-receptor activation by env determines the mechanism of death in HIV-infected and uninfected T lymphocytes

Abstract

There is considerable confusion concerning the mechanism of lymphocyte death during HIV infection. During the course of HIV infection, M-tropic viruses (R5) that use CCR5 chemokine coreceptors frequently evolve to T-tropic viruses (X4) that use CXCR4 receptors. In this study we show that activation of the CD4 or CCR5 receptor by R5 HIVenv causes a caspase 8–dependent death of both uninfected and infected CD4 T cells. In contrast, CXCR4 activation by X4 HIVenv induces a caspase-independent death of both uninfected CD4 and CD8 T cells and infected CD4 cells. These results suggest that activation of the chemokine receptor by HIVenv determines the mechanism of death for both infected and uninfected T lymphocytes.

Authors

Stacey R. Vlahakis, Alicia Algeciras-Schimnich, German Bou, Carrie J. Heppelmann, Angelina Villasis-Keever, Ronald G. Collman, Carlos V. Paya

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