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Citation Information: J Clin Invest. 1980;65(6):1257-1264. https://doi.org/10.1172/JCI109788.
Abstract
Captopril is a potent hypotensive agent whose efficacy has hitherto been attributed to its ability to alter either angiotensin II formation or kinin degradation. Our purpose was to examine captopril's acute effect on prostaglandin production, because changes in neither the renin-angiotensin nor the kallikrein-kinin systems appear adequate to account for the fall in arterial pressure. The plasma levels of angiotensin II, kinins, and prostaglandins were determined in response to increasing doses (5, 12.5, and 25 mg) of captopril and these responses were compared with the change in arterial pressure observed in nine supine normal male subjects studied on both a high (200 meq) and low (10 meq) sodium intake.
Authors
Stephen L. Swartz, Gordon H. Williams, Norman K. Hollenberg, Lawrence Levine, Robert G. Dluhy, Thomas J. Moore
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