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Research Article Free access | 10.1172/JCI109653

Monocytes do not inhibit peripheral blood erythroid burst forming unit colony formation.

J M Lipton, N A Link, J Breard, P L Jackson, B J Clarke, and D G Nathan

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Published January 1, 1980 - More info

Published in Volume 65, Issue 1 on January 1, 1980
J Clin Invest. 1980;65(1):219–223. https://doi.org/10.1172/JCI109653.
© 1980 The American Society for Clinical Investigation
Published January 1, 1980 - Version history
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Abstract

To determine a possible role of peripheral blood monocytes in erythroid differentiation, various fractions of peripheral blood mononuclear cells were prepared from normal volunteers. The fractions contained 3-95% monocytes. These freshly prepared monocytes did not inhibit erythroid burst forming unit expression in plasma clot erythroid colony culture. Null cell preparations contaminated by up to 84% monocytes expressed erythroid burst forming unit colony formation when either T lymphocytes or T-cell conditioned medium was added. These results indicate that certain peripheral blood null cells engage the program of erythroid differentiation in the presence of T cells and erythropoietin. Monocytes do not inhibit this engagement.

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