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Research Article Free access | 10.1172/JCI109622

Induction of suppressor activity in the autologous mixed lymphocyte reaction and in cultures with concanavalin A.

J B Innes, M M Kuntz, Y T Kim, and M E Weksler

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Published December 1, 1979 - More info

Published in Volume 64, Issue 6 on December 1, 1979
J Clin Invest. 1979;64(6):1608–1613. https://doi.org/10.1172/JCI109622.
© 1979 The American Society for Clinical Investigation
Published December 1, 1979 - Version history
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Abstract

T lymphocytes that are activated in the autologous mixed lymphocyte reaction (MLR) have suppressor activity. Concanavalin A (Con A) augments the suppressor activity generated in cultures containing both T and non-T lymphocytes and can induce suppressor activity in T-lymphocyte preparations that contain too few (10%) non-T cells to generate a significant autologous MLR. However, when such T-lymphocyte preparations are further depleted of adherent cells and contain less than 2% non-T cells, Con A fails to induce suppressor activity. These findings support the concept that an autologous MLR may play an important role in generation of suppressor cells by Con A.

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