Modulation of Cyclic Nucleotides in Isolated Rat Glomeruli: ROLE OF HISTAMINE, CARBAMYLCHOLINE, PARATHYROID HORMONE, AND ANGIOTENSIN-II

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Abstract

Because glomerular functions are modulated by numerous humoral agents, probably acting through cyclic nucleotides, the effects of some polypeptide hormones and biogenic amines on cyclic AMP (cAMP) and cyclic 3′,5′-guanosine monophosphate (cGMP) were studied in glomeruli isolated from rat renal cortex. Glomeruli and cortical tubules were prepared by a combination of sieving and density-gradient centrifugation. Under basal conditions, the contents of cAMP and cGMP in glomeruli were significantly higher than in tubules and unfractionated renal cortical tissue.

Authors

Vicente E. Torres, Thomas E. Northrup, Richard M. Edwards, Sudhir V. Shah, Thomas P. Dousa