Renal Net Glucose Release In Vivo and Its Contribution to Blood Glucose in Rats

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Abstract

This study describes the contribution of de novo glucose synthesis by the kidney to blood glucose homeostasis in rats. The net glucose release by the kidney in vivo was measured by an isotope-dilution method, which calculated the extent of dilution of injected [14C]glucose by glucose newly synthesized in the kidney. The extent of dilution was determined from the difference between the decrease of the actual blood glucose concentration and that of the radioactivity of [14C]glucose, after injecting [14C]glucose into functionally hepatectomized rats.

Authors

Kaichi Kida, Shinjiro Nakajo, Fumitada Kamiya, Yoshiko Toyama, Takashi Nishio, Hachiro Nakagawa