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Research Article Free access | 10.1172/JCI107561

Antibiotic Levels in Pericardial Fluid

James S. Tan, John C. Holmes, Noble O. Fowler, George T. Manitsas, and John P. Phair

Infectious Disease Division, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229

Division of Cardiology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229

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Infectious Disease Division, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229

Division of Cardiology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229

Find articles by Holmes, J. in: JCI | PubMed | Google Scholar

Infectious Disease Division, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229

Division of Cardiology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229

Find articles by Fowler, N. in: JCI | PubMed | Google Scholar

Infectious Disease Division, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229

Division of Cardiology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229

Find articles by Manitsas, G. in: JCI | PubMed | Google Scholar

Infectious Disease Division, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229

Division of Cardiology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229

Find articles by Phair, J. in: JCI | PubMed | Google Scholar

Published January 1, 1974 - More info

Published in Volume 53, Issue 1 on January 1, 1974
J Clin Invest. 1974;53(1):7–12. https://doi.org/10.1172/JCI107561.
© 1974 The American Society for Clinical Investigation
Published January 1, 1974 - Version history
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Abstract

An experimental model was designed to study the ability of antibiotics to enter the pericardial compartment. Noninfected and infected pericardial fluid and serum antibiotic activities were determined in adult mongrel dogs before and at intervals after antibiotic administration. After the administration of penicillin G, methicillin, cephaloridine, streptomycin, or gentamicin, clinically adequate antibiotic levels in the noninfected pericardial fluid were obtained within 1 h, and these levels approached or exceeded the serum levels within 2-4 h. Antibiotic levels obtained from infected dog pericardial fluids were higher than those from noninfected animals. Patients' serum and pericardial fluid antibiotic levels were measured after penicillin G, penicillin V, cephalothin, and gentamicin administration. We have found, both in the canine and human studies, that pericardial antibiotic levels taken at least 2 h after antibiotic administration are almost identical to those in the blood.

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