Usage Information
Citation Information: J Clin Invest. 1973;52(10):2495-2506. https://doi.org/10.1172/JCI107440.
Abstract
In an effort to elucidate the nature of the collagen-platelet interaction, the effects of collagen modification on platelet aggregation have been studied. We have shown that purified rat skin (salt) soluble collagen is effective at about 20 nM in mediating platelet aggregation in human platelet-rich plasma. This concentration is somewhat greater than that required of several skin insoluble collagens (ca. 10 nM). Both the α1(I) and α2 chains from rat skin soluble collagen produced platelet aggregation, but only at concentrations of about 13 μM and 55 μM, respectively. In contrast, heat-denatured collagen and chains (e.g., 65 μM α1(I) and 160 μM α2) failed to induce platelet aggregation and to inhibit platelet aggregation by native collagen.
Authors
David Puett, Betty Kay Wasserman, John D. Ford, Leon W. Cunningham
Usage data is cumulative from February 2024 through February 2025.
| Usage | JCI | PMC |
|---|---|---|
| Text version | 124 | 5 |
| 58 | 53 | |
| Scanned page | 348 | 10 |
| Citation downloads | 46 | 0 |
| Totals | 576 | 68 |
| Total Views | 644 | |
Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.
Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)