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Research Article Free access | 10.1172/JCI107314

In Vitro Myelosuppression and Immunosuppression by Ethanol

Glenn Tisman and Victor Herbert

Department of Medicine, Bronx Veterans Administration Hospital, New York 10468

Department of Pathology, Columbia University College of Physicians and Surgeons, New York 10032

Find articles by Tisman, G. in: JCI | PubMed | Google Scholar

Department of Medicine, Bronx Veterans Administration Hospital, New York 10468

Department of Pathology, Columbia University College of Physicians and Surgeons, New York 10032

Find articles by Herbert, V. in: JCI | PubMed | Google Scholar

Published June 1, 1973 - More info

Published in Volume 52, Issue 6 on June 1, 1973
J Clin Invest. 1973;52(6):1410–1414. https://doi.org/10.1172/JCI107314.
© 1973 The American Society for Clinical Investigation
Published June 1, 1973 - Version history
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Abstract

Concentrations of ethanol similar to those in the blood of intoxicated patients suppressed phytohemagglutinin- or streptolysin O-induced lymphocyte transformation, and inhibited bone marrow granulocyte colony growth in soft agar. Inhibition of lymphocyte transformation and granulocyte colony growth occurred despite the presence of large concentrations of folate and other vitamins. These in vitro findings may relate to in vivo effects of ethanol on myeloid and lymphoid tissue.

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