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Reflex Vascular Responses to Left Ventricular Outflow Obstruction and Activation of Ventricular Baroreceptors in Dogs
Allyn L. Mark, … , Phillip G. Schmid, Donald D. Heistad
Allyn L. Mark, … , Phillip G. Schmid, Donald D. Heistad
Published May 1, 1973
Citation Information: J Clin Invest. 1973;52(5):1147-1153. https://doi.org/10.1172/JCI107281.
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Research Article

Reflex Vascular Responses to Left Ventricular Outflow Obstruction and Activation of Ventricular Baroreceptors in Dogs

Abstract

Reflex vascular responses to acute left ventricular outflow obstruction were studied in anesthetized dogs. The studies were done to compare the effects of activation of ventricular baroreceptors on vascular resistance in skeletal muscle (gracilis muscle) and skin (hindpaw); to identify afferent and efferent pathways which mediate the reflex vasodilatation; and to assess the relative contribution of ventricular baroreceptors and baroreceptors in left atrium and pulmonary vessels in responses to left ventricular outflow obstruction. The gracilis artery and the cranial tibial artery to the paw were perfused separately at constant flow. Changes in perfusion pressure to each bed reflected changes in vascular resistance. Outflow obstruction was produced by inflating a balloon in the left ventricular outflow tract for 15 s while pressures in the left ventricle and aortic arch were measured.

Authors

Allyn L. Mark, Francois M. Abboud, Phillip G. Schmid, Donald D. Heistad

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