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Citation Information: J Clin Invest. 1972;51(8):1933-1938. https://doi.org/10.1172/JCI106999.
Abstract
The bone marrow-derived (B) lymphocyte can be identified by the presence of easily detectable surface immunoglobulin and a receptor for antigen-antibody-complement complexes (EAC′). Monocytes and macrophages also bear a receptor for EAC′ and in addition possess a receptor for red cell-IgG complexes (EA). Thymus-derived (T) lymphocytes bear neither of these receptors. The cells of 15 patients with leukemia and 19 human lymphoblastoid cell lines were examined for the presence of the EAC′ and EA receptors. Of the human leukemias studied, only the cells from the patients with chronic lymphatic leukemia (CLL) possess the EAC′ receptor. The EA receptor could not be demonstrated on CLL cells; hence, CLL cells bear the lymphocyte EAC′ receptor and by this criteria represent B lymphocytes. 12/19 of the cell lines studied could be classified as B lymphocytes by the presence of the EAC′ receptor and absence of the EA receptor. 2/19 cell lines possessed both the EAC′ and EA receptors and thus resemble the monocyte. 5/19 cell lines had no detectable receptor for EAC′ or EA. The approach presented in this study for the classification of leukemias and cell lines as to their B lymphocyte, T lymphocyte, or monocyte origin may have useful diagnostic and therapeutic implications.
Authors
Ethan M. Shevach, Ronald Herberman, Michael M. Frank, Ira Green
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