The glomerular mesangium: I. Kinetic studies of macromolecular uptake in normal and nephrotic rats

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Abstract

This study was designed to define quantitatively the function of the rat glomerular mesangium in the uptake and processing of intravenously administered protein macromolecules (radiolabeled aggregated human IgG, AHIgG-125I), to relate this function to that of the general reticuloendothelial system, and to examine the effects of increased glomerular permeability to protein on the mesangial cell system.

Authors

S. Michael Mauer, Alfred J. Fish, Edward B. Blau, Alfred F. Michael