Studies on the prekallikrein (kallikreinogen)—kallikrein enzyme system of human plasma: II. Evidence relating the kaolin-activated arginine esterase to plasma kallikrein

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Abstract

Evidence is presented in this paper that the kaolin-activated arginine esterase of plasma is related to plasma kallikrein activity. Such a relationship is based on studies that (1) establish a constant ratio of esterase activity on various synthetic substrates for the kaolin-activated arginine esterase, purified kallikrein(s), and preparations obtained during the fractionation procedure; (2) exclude other known plasma and tissue arginine esterases; (3) confirm the requirement for factor XII in the activation of the enzyme precursor; and (4) show similarities in behavior between the plasma esterase and purified kallikrein(s) toward a variety of inhibitors.

Authors

Robert W. Colman, Lawrence Mattler, Sol Sherry