Advertisement
Research Article Free access | 10.1172/JCI105585
National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Investigations, Clinical Physiology Section, and the National Cancer Institute, Medicine Branch, Bethesda, Md.
†Address requests for reprints to Dr. John N. Sheagren, National Institute of Allergy and Infectious Diseases, Bethesda, Md. 20014.
*Submitted for publication November 28, 1966; accepted February 2, 1967.
Presented in part at the Annual Meetings of the American Federation for Clinical Research, May 1, 1966, and abstracted in Clin. Res. 1966, 14, 360.
Find articles by Sheagren, J. in: JCI | PubMed | Google Scholar
National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Investigations, Clinical Physiology Section, and the National Cancer Institute, Medicine Branch, Bethesda, Md.
†Address requests for reprints to Dr. John N. Sheagren, National Institute of Allergy and Infectious Diseases, Bethesda, Md. 20014.
*Submitted for publication November 28, 1966; accepted February 2, 1967.
Presented in part at the Annual Meetings of the American Federation for Clinical Research, May 1, 1966, and abstracted in Clin. Res. 1966, 14, 360.
Find articles by Block, J. in: JCI | PubMed | Google Scholar
National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Investigations, Clinical Physiology Section, and the National Cancer Institute, Medicine Branch, Bethesda, Md.
†Address requests for reprints to Dr. John N. Sheagren, National Institute of Allergy and Infectious Diseases, Bethesda, Md. 20014.
*Submitted for publication November 28, 1966; accepted February 2, 1967.
Presented in part at the Annual Meetings of the American Federation for Clinical Research, May 1, 1966, and abstracted in Clin. Res. 1966, 14, 360.
Find articles by Wolff, S. in: JCI | PubMed | Google Scholar
Published May 1, 1967 - More info
Phagocytic function of the reticuloendothelial system as measured by the clearance of 125I-labeled aggregated human serum albumin (AA) was studied in patients with Hodgkin's disease. Each more advanced stage of the disease was associated with more rapid clearance of the AA. Production of remission by radiation therapy or by chemotherapy was associated in some patients with slowing of the clearance rate, whereas relapse seemed to be associated with acceleration. Thus, impaired phagocytosis cannot be implicated in the several defects in immunity known to be present in Hodgkin's disease. Furthermore, determination of the clearance rate of AA in patients with Hodgkin's disease may have clinical usefulness as another indicator of extent or activity of disease.
Images.