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Usage Information

The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus
Michael P. Cancro, David P. D’Cruz, Munther A. Khamashta
Michael P. Cancro, David P. D’Cruz, Munther A. Khamashta
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Science in Medicine

The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus

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Abstract

SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a soluble ligand of the TNF cytokine family, is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. High levels of BLyS may relax B cell selection and contribute to autoantibody production, exacerbating the SLE disease state. This review discusses the mechanism of BLyS action on B cells, its role in SLE, and specific targeting of BLyS in the treatment of SLE.

Authors

Michael P. Cancro, David P. D’Cruz, Munther A. Khamashta

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Usage data is cumulative from August 2025 through August 2026.

Usage JCI PMC
Text version 1,749 463
PDF 245 94
Figure 441 7
Table 105 0
Citation downloads 201 0
Totals 2,741 564
Total Views 3,305
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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