Advertisement
Research Article Free access | 10.1172/JCI109638
Find articles by Kondo, T. in: JCI | PubMed | Google Scholar
Find articles by Beutler, E. in: JCI | PubMed | Google Scholar
Published January 1, 1980 - More info
The developmental changes in the capacity for D-glucose transport of guinea pig erythrocyte membranes were compared to alterations in the electrophoretic pattern of erythrocyte membrane components. Guinea pig erythrocytes lose their D-glucose carrier functions during development. Good correlation was observed between the loss of glucose uptake and apparent decrease of the zone 4.5 of Coomassie Blue-stained membrane proteins on electrophoresis. Reconstitution of membrane preparations in liposomes resulted in a parallel change in the D-glucose uptake and D-glucose penetration of intact erythrocytes. This suggests that the decrease of D-glucose transport capacity during development is caused by the loss of one or more protein components from the erythrocyte membranes.
Click on an image below to see the page. View PDF of the complete article