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Research Article Free access | 10.1172/JCI106125
Medical Research Center and the Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Victoria, Australia, 3004
Department of Statistics, University of Melbourne, Melbourne, Victoria, Australia, 3052
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Medical Research Center and the Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Victoria, Australia, 3004
Department of Statistics, University of Melbourne, Melbourne, Victoria, Australia, 3052
Find articles by Burger, H. in: JCI | PubMed | Google Scholar
Medical Research Center and the Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Victoria, Australia, 3004
Department of Statistics, University of Melbourne, Melbourne, Victoria, Australia, 3052
Find articles by Catt, K. in: JCI | PubMed | Google Scholar
Medical Research Center and the Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Victoria, Australia, 3004
Department of Statistics, University of Melbourne, Melbourne, Victoria, Australia, 3052
Find articles by Doig, A. in: JCI | PubMed | Google Scholar
Published September 1, 1969 - More info
The nature of the disappearance of radioiodinated human growth hormone (HGH) from plasma has been reexamined. The metabolic clearance rate (MCR) was determined both from single injection and constant infusion studies. After single injection of highly purified radioiodinated HGH, the disappearance curve remained multiexponential during the period of study (4 hr). The shape of the curve was independent of the growth hormone preparation used. Similar disappearance curves were obtained with unlabeled HGH.
MCR values calculated from constant infusion studies were 203 ±7.8 liters/day per m2 and values derived from single injection studies agreed closely with this.
The multiexponential nature of the disappearance curve does not permit meaningful calculation of volume of distribution or half-time of disappearance.