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Video abstracts

In this video collection, authors of findings published in JCI Insight present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Video Abstracts Guidelines page.

Detrimental effects of suboptimal hydration

In this episode, Natalia Dmitrieva and colleagues show that improper hydration throughout life associates with several detrimental effects on long-term health.


A long non-coding RNA marker of isolated human islet quality


In this episode, Wilson Wong, Wayne Hawthorne, Mugdha Joglekar, Anand Hardikar, and colleagues identify a long non-coding RNA signature that is predictive of the quality human cadaver-derived pancreatic islets


Enhanced mitochondrial fusion suppresses pancreatic cancer

In this episode, Cullen Taniguchi, Meifang Yu, Nicholas Nguyen, and colleagues demonstrate that enhancing mitochondrial fusion in pancreatic cancer cells induces mitophagy, which alters tumor energetics and correlates with improved survival in mouse models…


Inner blood-retina barrier dysfunction linked to retina cell atrophy

In this episode, Matthew Campbell, Natalie Hudson, and colleagues show that blood vessels of the inner retina are highly dynamic and that loss of inner blood-retina barrier integrity may underlie age-related macular degeneration.


High-salt diet-induced microbiome alterations linked to hypertension

In this episode, Annet Kirabo, Jane Ferguson, and colleagues provide evidence that high-salt diet-induced changes in the gut microbiome promote dendritic cell activation, leading to inflammation and hypertension.

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