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Regulating bile duct epithelial injury in erythroid cells
In this episode, Li Yang and colleagues discuss how hepatic CD71+ erythroid cells play an immunoregulatory role in biliary atresia by suppressing the activation of hepatic lymphocytes...
Published June 4, 2020
Video Abstracts
Diabetes-associated genetic variation alters insulin secretion
In this Episode, Adrian Vella and colleagues discuss abnormal insulin pulse characteristics in non-diabetic individuals are linked with diabetes-associated variation in TCF7L2 and may serve as early markers of β cell dysfunction...
Published April 9, 2020
Video Abstracts
Drug delivery platform targets lower airway inflammation
In this episode, Krishnendu Roy, Rabindra Tirouvanziam, Amit Gaggar, and colleagues describe the development of a drug delivery platform that allows direct targeting of lung neutrophils under inflammatory conditions…
Published December 5, 2019
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Composite signature for prediction of T1D progression
In this episode, Cate Speake and colleagues employ an analytical method that incorporates reproducibility testing to identify a composite signature prognostic for type 1 diabetes disease progression after diagnosis…
Published December 5, 2019
Video Abstracts
Itch in the gut
In this episode, Stuart Brierley and colleagues link itch in the gut to nerve sensitization and chronic intestinal pain and provide an animation illustrating the potential clinical implications of this work...
Published October 17, 2019
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Detrimental effects of suboptimal hydration
In this episode, Natalia Dmitrieva and colleagues show that improper hydration throughout life associates with several detrimental effects on long-term health...
Published September 5, 2019
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A long non-coding RNA marker of isolated human islet quality
In this episode, Wilson Wong, Wayne Hawthorne, Mugdha Joglekar, Anand Hardikar, and colleagues identify a long non-coding RNA signature that is predictive of the quality human cadaver-derived pancreatic islets…
Published August 22, 2019
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Enhanced mitochondrial fusion suppresses pancreatic cancer
In this episode, Cullen Taniguchi, Meifang Yu, Nicholas Nguyen, and colleagues demonstrate that enhancing mitochondrial fusion in pancreatic cancer cells alters tumor energetics and correlates with improved survival in mouse model...
Published August 22, 2019
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Inner blood-retina barrier dysfunction linked to retina cell atrophy
In this episode, Matthew Campbell, Natalie Hudson, and colleagues show that blood vessels of the inner retina are highly dynamic and that loss of the inner blood-retina barrier integrity may underlie age-related macular degeneration…
Published August 8, 2019
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High-salt diet-induced microbiome alterations linked to hypertension
In this episode, Annet Kirabo, Jane Ferguson, and colleagues provide evidence that high-salt diet-induced changes in the gut microbiome promote dendritic cell activation, leading to inflammation and hypertension…
Published August 7, 2019
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