Emerging roles for enteric glia in gastrointestinal disorders
Keith A. Sharkey
Keith A. Sharkey
Published February 17, 2015
Citation Information: J Clin Invest. 2015;125(3):918-925. https://doi.org/10.1172/JCI76303.
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Review Series

Emerging roles for enteric glia in gastrointestinal disorders

Abstract

Enteric glia are important components of the enteric nervous system (ENS) and also form an extensive network in the mucosa of the gastrointestinal (GI) tract. Initially regarded as passive support cells, it is now clear that they are actively involved as cellular integrators in the control of motility and epithelial barrier function. Enteric glia form a cellular and molecular bridge between enteric nerves, enteroendocrine cells, immune cells, and epithelial cells, depending on their location. This Review highlights the role of enteric glia in GI motility disorders and in barrier and defense functions of the gut, notably in states of inflammation. It also discusses the involvement of enteric glia in neurological diseases that involve the GI tract.

Authors

Keith A. Sharkey

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Figure 1

Schematic representation of the distribution of enteric glia in the GI tract.

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Schematic representation of the distribution of enteric glia in the GI t...
Subpopulations of enteric glia are located around all classes of neurons in the myenteric and submucosal plexuses and in the mucosa. In the mucosa, enteric glia lie below the epithelium and connect to the “neuropod” of enteroendocrine cells (EECs) to form a tripartite connection among enteric nerves, enteroendocrine cells, and enteric glia (see text for details). Enteric glia also form a functional bridge between immune cells. Dark blue indicates intrinsic primary afferent neurons; light blue, interneurons; orange, excitatory motor neurons; green, inhibitory motor neurons; purple, secretomotor neurons.