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The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

Tadahiro Kitamura, … , Karen C. Arden, Domenico Accili

Tadahiro Kitamura, … , Karen C. Arden, Domenico Accili

Published December 15, 2002
Citation Information: J Clin Invest. 2002;110(12):1839-1847. https://doi.org/10.1172/JCI16857.

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SIRT1 metabolic actions: Integrating recent advances from mouse models M Boutant, C Cantó	Molecular Metabolism	2013
SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and β-cell formation RH Wang, X Xu, HS Kim, Z Xiao, CX Deng	International journal of biological sciences	2013
FOXO1 competes with carbohydrate response element-binding protein (ChREBP) and inhibits thioredoxin-interacting protein (TXNIP) transcription in pancreatic beta cells C Kibbe, J Chen, G Xu, G Jing, A Shalev	The Journal of biological chemistry	2013
Insulin Receptor-Overexpressing β-Cells Ameliorate Hyperglycemia in Diabetic Rats through Wnt Signaling Activation MH Kim, SH Hong, MK Lee, B Wagner	PloS one	2013
Nov/Ccn3, a Novel Transcriptional Target of FoxO1, Impairs Pancreatic β-Cell Function R Paradis, N Lazar, P Antinozzi, B Perbal, J Buteau, FC Lynn	PloS one	2013
Modeling Integrated Cellular Machinery Using Hybrid Petri-Boolean Networks N Berestovsky, W Zhou, D Nagrath, L Nakhleh, M Singh	PLoS computational biology	2013
Critical physiological and pathological functions of Forkhead Box O tumor suppressors GR Dumitrascu, O Bucur	Discoveries	2013
β-Arrestin2 plays a key role in the modulation of the pancreatic beta cell mass in mice. Ravier MA, Leduc M, Richard J, Linck N, Varrault A, Pirot N, Roussel MM, Bockaert J, Dalle S, Bertrand G	Diabetologia	2013
β-Cell Regeneration Mediated by Human Bone Marrow Mesenchymal Stem Cells A Milanesi, JW Lee, Z Li, SD Sacco, V Villani, V Cervantes, L Perin, JS Yu	PloS one	2012
Role of Transcription Factor Modifications in the Pathogenesis of Insulin Resistance MY Kim, JS Bae, TH Kim, JM Park, YH Ahn	Experimental Diabetes Research	2012
FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization O Kikuchi, M Kobayashi, K Amano, T Sasaki, T Kitazumi, HJ Kim, YS Lee, H Yokota-Hashimoto, YI Kitamura, T Kitamura	PloS one	2012
Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis through Regulation of Chrebp O-Glycosylation Y Ido-Kitamura, T Sasaki, M Kobayashi, HJ Kim, YS Lee, O Kikuchi, H Yokota-Hashimoto, K Iizuka, D Accili, T Kitamura	PloS one	2012
A Simple Matter of Life and Death—The Trials of Postnatal Beta-Cell Mass Regulation E Tarabra, S Pelengaris, M Khan	International Journal of Endocrinology	2012
Human -Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map RN Kulkarni, EB Mizrachi, AG Ocana, AF Stewart	Diabetes	2012
Reduced expression of the LRP16 gene in mouse insulinoma (MIN6) cells exerts multiple effects on insulin content, proliferation and apoptosis X Li, B Xue, X Wang, L Sun, T Zhang, L Qu, X Zou, Y Mu	Journal of Huazhong University of Science and Technology [Medical Sciences]	2012
Modulation of hypovitaminosis D-induced islet dysfunction and insulin resistance through direct suppression of the pancreatic islet renin–angiotensin system in mice Q Cheng, BJ Boucher, PS Leung	Diabetologia	2012
Generation of functional insulin-producing cells in the gut by Foxo1 ablation C Talchai, S Xuan, T Kitamura, RA DePinho, D Accili	Nature Genetics	2012
Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8) S Cuesta, R Kireev, C García, L Rancan, E Vara, JA Tresguerres	AGE	2012
The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress L Yan, S Guo, M Brault, J Harmon, RP Robertson, R Hamid, R Stein, E Yang	Biochemical Journal	2012
Dual regulatory role for phosphatase and tensin homolog in specification of intestinal endocrine cell subtypes SA Roy, MJ Langlois, JC Carrier, F Boudreau, N Rivard, N Perreault	World journal of gastroenterology : WJG	2012
Differential regulation of embryonic and adult β cell replication U Gunasekaran, CW Hudgens, BT Wright, MF Maulis, M Gannon	Cell cycle (Georgetown, Tex.)	2012
Identification of direct forkhead box O1 targets involved in palmitate-induced apoptosis in clonal insulin-secreting cells using chromatin immunoprecipitation coupled to DNA selection and ligation HY Lin, Y Yin, JX Zhang, H Xuan, Y Zheng, SS Zhan, YX Zhu, X Han	Diabetologia	2012
Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure C Talchai, S Xuan, HV Lin, L Sussel, D Accili	Cell	2012
Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB Y Zhang, W Zhen, P Maechler, D Liu	The Journal of Nutritional Biochemistry	2012
Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells R Isaac, S Boura-Halfon, D Gurevitch, A Shainskaya, Y Levkovitz, Y Zick	The Journal of biological chemistry	2012
Involvement of Oxidative Stress in Suppression of Insulin Biosynthesis under Diabetic Conditions H Kaneto, TA Matsuoka	International journal of molecular sciences	2012
Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation W Kim, Q Lao, YK Shin, OD Carlson, EK Lee, M Gorospe, RN Kulkarni, JM Egan	Science signaling	2012
FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis A Kode, I Mosialou, BC Silva, S Joshi, M Ferron, MT Rached, S Kousteni	The Journal of biological chemistry	2012
Forkhead Box O1 Is Present in Quiescent Pituitary Cells during Development and Is Increased in the Absence of p27Kip1 S Majumdar, CL Farris, BE Kabat, DO Jung, BS Ellsworth, TW Kay	PloS one	2012
JNK3 Maintains Expression of the Insulin Receptor Substrate 2 (IRS2) in Insulin-Secreting Cells: Functional Consequences for Insulin Signaling S Abdelli, C Bonny, G Sesti	PloS one	2012
Neutralizing Interleukin-1β (IL-1β) Induces β-Cell Survival by Maintaining PDX1 Protein Nuclear Localization* A Ardestani, NS Sauter, F Paroni, G Dharmadhikari, JH Cho, R Lupi, P Marchetti, J Oberholzer, JK Conte, K Maedler	The Journal of biological chemistry	2011
Diabetes in Mice With Selective Impairment of Insulin Action in Glut4-Expressing Tissues HV Lin, H Ren, VT Samuel, HY Lee, TY Lu, GI Shulman, D Accili	Diabetes	2011
New aspects of melanocortin signaling: A role for PRCP in α-MSH degradation S Diano	Frontiers in Neuroendocrinology	2011
PGC-1 coactivators in the control of energy metabolism C Liu, JD Lin	Acta Biochimica et Biophysica Sinica	2011
AGEs Decrease Insulin Synthesis in Pancreatic β-Cell by Repressing Pdx-1 Protein Expression at the Post-Translational Level T Shu, Y Zhu, H Wang, Y Lin, Z Ma, X Han, K Stadler	PloS one	2011
Association analyses between the genetic polymorphisms of HNF4A and FOXO1 genes and Chinese Han patients with type 2 diabetes T Li, X Wu, X Zhu, J Li, L Pan, P Li, Z Xin, Y Liu	Molecular and Cellular Biochemistry	2011
FoxO1, the transcriptional chief of staff of energy metabolism S Kousteni	Bone	2011
Forkhead Homeobox Type O Transcription Factors in the Responses to Oxidative Stress P Storz	Antioxidants & Redox Signaling	2011
Dissociation of the Glucose and Lipid Regulatory Functions of FoxO1 by Targeted Knockin of Acetylation-Defective Alleles in Mice AS Banks, JY Kim-Muller, TL Mastracci, NM Kofler, L Qiang, RA Haeusler, MJ Jurczak, D Laznik, G Heinrich, VT Samuel, GI Shulman, VE Papaioannou, D Accili	Cell Metabolism	2011
40 Isoform of p53 Controls -Cell Proliferation and Glucose Homeostasis in Mice C Hinault, D Kawamori, CW Liew, B Maier, J Hu, SR Keller, RG Mirmira, H Scrable, RN Kulkarni	Diabetes	2011
Differential and Complementary Effects of Glucose and Prolactin on Islet DNA Synthesis and Gene Expression R Arumugam, D Fleenor, D Lu, M Freemark	Endocrinology	2011
Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6) G Meur, Q Qian, GS Xavier, TJ Pullen, T Tsuboi, C McKinnon, L Fletcher, JM Tavaré, S Hughes, P Johnson, GA Rutter	The Journal of biological chemistry	2011
Two Tales of Antioxidant Enzymes on β Cells and Diabetes XG Lei, MZ Vatamaniuk	Antioxidants & Redox Signaling	2011
FoxOs: Unifying Links Between Oxidative Stress and Skeletal Homeostasis S Kousteni	Current Osteoporosis Reports	2011
Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell mass B Portha, C Tourrel-Cuzin, J Movassat	Experimental Diabetes Research	2011
Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models Z Cheng, MF White	Antioxidants & Redox Signaling	2011
Metabolic syndrome as a risk factor for neurological disorders AA Farooqui, T Farooqui, F Panza, V Frisardi	Cellular and Molecular Life Sciences	2011
Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus F Folli, T Okada, C Perego, J Gunton, CW Liew, M Akiyama, A D'Amico, SL Rosa, C Placidi, R Lupi, P Marchetti, G Sesti, M Hellerstein, L Perego, RN Kulkarni	PloS one	2011
Rictor/mTORC2 Is Essential for Maintaining a Balance Between -Cell Proliferation and Cell Size Y Gu, J Lindner, A Kumar, W Yuan, MA Magnuson	Diabetes	2011
Suppression of FoxO1 Activity by Long-Chain Fatty Acyl Analogs G Zatara, R Hertz, M Shaked, N Mayorek, E Morad, E Grad, A Cahan, HD Danenberg, TG Unterman, J Bar-Tana	Diabetes	2011
Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic -Cells W Kim, ME Doyle, Z Liu, Q Lao, YK Shin, OD Carlson, HS Kim, S Thomas, JK Napora, EK Lee, R Moaddel, Y Wang, S Maudsley, B Martin, RN Kulkarni, JM Egan	Diabetes	2011
PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure P Bai, C Canto, A Brunyánszki, A Huber, M Szántó, Y Cen, H Yamamoto, SM Houten, B Kiss, H Oudart, P Gergely, J Menissier-de Murcia, V Schreiber, AA Sauve, J Auwerx	Cell Metabolism	2011
FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic -Cells Is Distinct From That in Hepatocytes S Tsunekawa, D Demozay, I Briaud, J McCuaig, D Accili, R Stein, CJ Rhodes	Diabetes	2011
Transcriptional Regulation of Neuronal Polarity and Morphogenesis in the Mammalian Brain L de la Torre-Ubieta, A Bonni	Neuron	2011
Betacellulin-Induced Beta Cell Proliferation and Regeneration Is Mediated by Activation of ErbB-1 and ErbB-2 Receptors YS Oh, S Shin, YJ Lee, EH Kim, HS Jun, K Maedler	PloS one	2011
Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells. Srivastava RK, Tang SN, Zhu W, Meeker D, Shankar S	Frontiers in bioscience (Elite edition)	2011
FOXO1: A potential target for human diseases Lu H, Huang H	Current drug targets	2011
Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Improves β-Cell Function Under Stress D Gurevitch, S Boura-Halfon, R Isaac, G Shahaf, M Alberstein, D Ronen, EC Lewis, Y Zick	Diabetes	2010
Role of Insulin-Like Growth Factor-Binding Protein 5 (IGFBP5) in Organismal and Pancreatic β-Cell Growth CE Gleason, Y Ning, TP Cominski, R Gupta, KH Kaestner, JE Pintar, MJ Birnbaum	Molecular Endocrinology	2010
From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis SC Manolagas	Endocrine reviews	2010
Insulin secretion and insulin-producing tumors JM Guettier, P Gorden	Expert Review of Endocrinology & Metabolism	2010
Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis H Kaneto, N Katakami, M Matsuhisa, T Matsuoka	Mediators of Inflammation	2010
FoxOs Function Synergistically to Promote Glucose Production* RA Haeusler, KH Kaestner, D Accili	The Journal of biological chemistry	2010
Foxo1, a Novel Regulator of Osteoblast Differentiation and Skeletogenesis* CC Teixeira, Y Liu, LM Thant, J Pang, G Palmer, M Alikhani	The Journal of biological chemistry	2010
Uncoupling of Acetylation from Phosphorylation Regulates FoxO1 Function Independent of Its Subcellular Localization* L Qiang, AS Banks, D Accili	The Journal of biological chemistry	2010
Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice Y Liu, K Tanabe, D Baronnier, S Patel, J Woodgett, C Cras-Méneur, MA Permutt	Diabetologia	2010
Akt isoforms and glucose homeostasis - the leptin connection N Hay	Trends in endocrinology and metabolism: TEM	2010
Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents S Georgia, C Hinault, D Kawamori, J Hu, J Meyer, M Kanji, A Bhushan, RN Kulkarni	Diabetes	2010
Genetic Analysis of Type-1 Insulin-like Growth Factor Receptor Signaling through Insulin Receptor Substrate-1 and -2 in Pancreatic β Cells* S Xuan, M Szabolcs, F Cinti, S Perincheri, D Accili, A Efstratiadis	The Journal of biological chemistry	2010
Hepatic FoxO1 Ablation Exacerbates Lipid Abnormalities during Hyperglycemia* RA Haeusler, S Han, D Accili	The Journal of biological chemistry	2010
Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition K Fulzele, RC Riddle, DJ DiGirolamo, X Cao, C Wan, D Chen, MC Faugere, S Aja, MA Hussain, JC Brüning, TL Clemens	Cell	2010
Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure O Kluth, F Mirhashemi, S Scherneck, D Kaiser, R Kluge, S Neschen, HG Joost, A Schürmann	Diabetologia	2010
Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer SK Roy, RK Srivastava, S Shankar	Journal of molecular signaling	2010
Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update JS Bae, TH Kim, MY Kim, JM Park, YH Ahn	Sensors (Basel, Switzerland)	2010
NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of β-Cells via JNK, p38 MAPK and p53 Pathways H Yuan, X Zhang, X Huang, Y Lu, W Tang, Y Man, S Wang, J Xi, J Li, JM Gimble	PloS one	2010
The Osteoblast, a Novel Site of Action for FoxO1 Regulation of Glucose Homeostasis Marie-Therese Rached, Aruna Kode, Barbara C Silva, Dae Young Jung, Susan J Gray, Helena Ong, Ji-Hye Paik, Ronald A DePinho, Jason Kim, Gerard Karsenty, Stavroula Kousteni	Journal of Clinical Investigation	2009
Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1 T Kitamura, YI Kitamura, M Kobayashi, O Kikuchi, T Sasaki, RA Depinho, D Accili	Molecular and cellular biology	2009
Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion MM Sachdeva, DA Stoffers	Molecular Endocrinology	2009
FoxO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratrol GK Ganjam, EY Dimova, TG Unterman, T Kietzmann	The Journal of biological chemistry	2009
FoxO1 Haploinsufficiency Protects Against High-Fat Diet-Induced Insulin Resistance With Enhanced Peroxisome Proliferator-Activated Receptor Activation in Adipose Tissue JJ Kim, P Li, J Huntley, JP Chang, KC Arden, JM Olefsky	Diabetes	2009
Growth factor control of pancreatic islet regeneration and function A Assmann, C Hinault, RN Kulkarni	Pediatric Diabetes	2009
Akt and PTEN: β-cell mass and pancreas plasticity L Elghazi, E Bernal-Mizrachi	Trends in Endocrinology & Metabolism	2009
Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases RK Humphrey, SM Yu, LE Flores, US Jhala	The Journal of biological chemistry	2009
Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic -Cells Leads to Increased -Cell Mass and Prevention of Hyperglycemia S Hamada, K Hara, T Hamada, H Yasuda, H Moriyama, R Nakayama, M Nagata, K Yokono	Diabetes	2009
Pdx1 and other factors that regulate pancreatic β-cell survival K Fujimoto, KS Polonsky	Diabetes, Obesity and Metabolism	2009
Effect of forkhead box O1 (FOXO1) on beta cell development in the human fetal pancreas M Al-Masri, M Krishnamurthy, J Li, GF Fellows, HH Dong, CG Goodyer, R Wang	Diabetologia	2009
The role of FOXO in the regulation of metabolism DN Gross, M Wan, MJ Birnbaum	Current Diabetes Reports	2009
Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe? AV Nunn, JD Bell, GW Guy	Nutrition & Metabolism	2009
Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function L Shu, AV Matveyenko, J Kerr-Conte, JH Cho, CH McIntosh, K Maedler	Human Molecular Genetics	2009
FoxO gene family evolution in vertebrates M Wang, X Zhang, H Zhao, Q Wang, Y Pan	BMC Evolutionary Biology	2009
Insulin Acts through FOXO3a to Activate Transcription of Plasminogen Activator Inhibitor Type 1 UR Jag, J Zavadil, FM Stanley	Molecular Endocrinology	2009
Insulin Receptor Substrate-2 in β-Cells Decreases Diabetes in Nonobese Diabetic Mice LD Norquay, KE D'Aquino, LM Opare-Addo, A Kuznetsova, M Haas, JA Bluestone, MF White	Endocrinology	2009
Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice Y Shigeyama, T Kobayashi, Y Kido, N Hashimoto, SI Asahara, T Matsuda, A Takeda, T Inoue, Y Shibutani, M Koyanagi, T Uchida, M Inoue, O Hino, M Kasuga, T Noda	Molecular and cellular biology	2008
Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance K Tanabe, Z Liu, S Patel, BW Doble, L Li, C Cras-Méneur, SC Martinez, CM Welling, MF White, E Bernal-Mizrachi, JR Woodgett, MA Permutt	PLoS Biology	2008
Inhibition of gluconeogenesis in primary hepatocytes by stromal cell-derived factor-1 (SDF-1) through a c-Src/Akt-dependent signaling pathway HY Liu, GB Wen, J Han, T Hong, D Zhuo, Z Liu, W Cao	The Journal of biological chemistry	2008
Mechanisms of Disease: using genetically altered mice to study concepts of type 2 diabetes D Leroith, D Accili	Nature Clinical Practice Endocrinology & Metabolism	2008
Mice with beta cell overexpression of glycogen synthase kinase-3β have reduced beta cell mass and proliferation Z Liu, K Tanabe, E Bernal-Mizrachi, MA Permutt	Diabetologia	2008
Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice XD Wang, MZ Vatamaniuk, SK Wang, CA Roneker, RA Simmons, XG Lei	Diabetologia	2008
The Role of Incretins in Glucose Homeostasis and Diabetes Treatment W Kim, JM Egan	Pharmacological reviews	2008
Pleiotropic Roles of PDX-1 in the Pancreas H Kaneto, T Miyatsuka, D Kawamori, TA Matsuoka	The review of diabetic studies : RDS	2008
Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets T Kato, H Shimano, T Yamamoto, M Ishikawa, S Kumadaki, T Matsuzaka, Y Nakagawa, N Yahagi, M Nakakuki, AH Hasty, Y Takeuchi, K Kobayashi, A Takahashi, S Yatoh, H Suzuki, H Sone, N Yamada	Diabetes	2008
Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor S Shankar, Q Chen, RK Srivastava	Journal of molecular signaling	2008
Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction G Millien, J Beane, M Lenburg, PN Tsao, J Lu, A Spira, MI Ramirez	Gene Expression Patterns	2008
The Interplay of Prolactin and the Glucocorticoids in the Regulation of β-Cell Gene Expression, Fatty Acid Oxidation, and Glucose-Stimulated Insulin Secretion: Implications for Carbohydrate Metabolism in Pregnancy R Arumugam, E Horowitz, D Lu, JJ Collier, S Ronnebaum, D Fleenor, M Freemark	Endocrinology	2008
Requirement for glucokinase Irs2 in order to achieve compensatory beta-cell hyperplasia in response to high-fat-diet-induced insulin resistance Yasuo Terauchi, Iseki Takamoto, Naoto Kubota, Junji Matsui, Ryo Suzuki, Kajuro Komeda, Akemi Hara, Yukiyasu Toyoda, Ichitomo Miwa, Shinichi Aizawa, Shuichi Tsutsumi, Yoshiharu Tsubamoto, Shinji Hashimoto, Kazuhiro Eto, Akinobu Nakamura, Mitsuhiko Noda, Kazuyuki Tobe, Hiroyuki Aburatani, Ryozo Nagai, Takashi Kadowaki	Journal of Clinical Investigation	2007
A Foxo/Notch pathway controls myogenic differentiation and fiber type specification Tadahiro Kitamura, Yukari Ido Kitamura, Yasuhiro Funahashi, Carrie L. Shawber, Diego H. Castrillon, Ramya Kollipara, Ronald A. DePinho, Jan Kitajewski and Domenico Accili	Journal of Clinical Investigation	2007
From the Cover: Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance T Okada, CW Liew, J Hu, C Hinault, MD Michael, J Krtzfeldt, C Yin, M Holzenberger, M Stoffel, RN Kulkarni	Proceedings of the National Academy of Sciences	2007
A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis DA Babu, TG Deering, RG Mirmira	Molecular Genetics and Metabolism	2007
Mechanisms of action of glucagon-like peptide 1 in the pancreas ME Doyle, JM Egan	Pharmacology & Therapeutics	2007
Glucolipotoxicity: fuel excess and beta-cell dysfunction V Poitout, RP Robertson	Endocrine reviews	2007
Continuous stimulation of human glucagon-like peptide-1 (7–36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes J Zhang, Y Tokui, K Yamagata, J Kozawa, K Sayama, H Iwahashi, K Okita, M Miuchi, H Konya, T Hamaguchi, M Namba, I Shimomura, J Miyagawa	Diabetologia	2007
Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance Haruka Okamoto, Marta Letizia Hribal, Hua V. Lin, William R. Bennett, Andrew Ward and Domenico Accili	Journal of Clinical Investigation	2006
Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism S Qu, J Altomonte, G Perdomo, J He, Y Fan, A Kamagate, M Meseck, HH Dong	Endocrinology	2006
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome JD Johnson, E Bernal-Mizrachi, EU Alejandro, Z Han, TB Kalynyak, H Li, JL Beith, J Gross, GL Warnock, RR Townsend, MA Permutt, KS Polonsky	Proceedings of the National Academy of Sciences	2006
Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus NG Smart, AA Apelqvist, X Gu, EB Harmon, JN Topper, RJ MacDonald, SK Kim	PLoS Biology	2006
In control of biology: of mice, men and Foxes PJ Wijchers, JP Burbach, MP Smidt	Biochemical Journal	2006
PGC-1α: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes S Soyal, F Krempler, H Oberkofler, W Patsch	Diabetologia	2006
Regulation of the insulin gene by glucose and fatty acids. Poitout V, Hagman D, Stein R, Artner I, Robertson RP, Harmon JS	The Journal of nutrition	2006
Involvement of FoxO transcription factors in angiogenesis and postnatal neovascularization Michael Potente, Carmen Urbich, Ken-ichiro Sasaki, Wolf K. Hofmann, Christopher Heeschen, Alexandra Aicher, Ramya Kollipara, Ronald A. DePinho, Andreas M. Zeiher & Stefanie Dimmeler	Journal of Clinical Investigation	2005
Timp3 deficiency in Insulin receptor haploinsufficient mice promotes glucose intolerance and vascular inflammation via increased TNF-α Massimo Federici, Marta L. Hribal, Rossella Menghini, Hiroko Kanno, Valentina Marchetti, Ottavia Porzio, Susan W. Sunnarborg, Stefano Rizza, Matteo Serino, Veronica Cunsolo, Davide Lauro, Alessandro Mauriello, David S. Smookler, Paolo Sbraccia, Giorgio Sesti, David C. Lee, Rama Khokha, Domenico Accili, Renato Lauro	Journal of Clinical Investigation	2005
Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells H Wang, M Iezzi, S Theander, PA Antinozzi, BR Gauthier, PA Halban, CB Wollheim	Diabetologia	2005
Diabetes outfoxed by GLP-1? GG Holz, OG Chepurny	Science's STKE : signal transduction knowledge environment	2005
Transcriptional feedback control of insulin receptor by dFOXO/FOXO1 O Puig, R Tjian	Genes & development	2005
Dysregulation of IRS2 in beta cells and brain causes obesity and diabetes Xueying Lin, Akiko Taguchi, Sunmin Park, Jake A. Kushner, Fan Li, Yedan Li, Morris F. White	Journal of Clinical Investigation	2004
Mosaic analysis of insulin receptor function Tadahiro Kitamura, Yukari Kitamura, Jun Nakae, Antonio Giordano, Saverio Cinti, C. Ronald Kahn, Argiris Efstratiadis, Domenico Accili	Journal of Clinical Investigation	2004
Impaired pancreatic growth, beta-cell mass and function in E2F1 -/- mice Lluis Fajas, Jean-Sébastien Annicotte, Stéphanie Miard, David Sarruf, Mitsuhiro Watanabe, and Johan Auwerx	Journal of Clinical Investigation	2004
Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus (TNDM) locus Dan Ma, Julian P. H. Shield, Wendy Dean, Isabelle Leclerc, Claude Knauf, Remy Burcelin, Guy A. Rutter, Gavin Kelsey	Journal of Clinical Investigation	2004
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia in response to insulin resistance Rohit N. Kulkarni, Ulupi S. Jhala, Jonathon N. Winnay, Marc R. Montminy & C. Ronald Kahn	Journal of Clinical Investigation	2004
Insulin secretory defect and increased susceptibility to experimental diabetes by reduction in Akt activity in pancreatic islet β-cells Ernesto Bernal-Mizrachi, Szabolcs Fatrai, James D. Johnson, Mitsuru Ohsugi, Kenichi Otani, Zhiqiang Han, Kenneth S. Polonsky, and M. Alan Permutt	Journal of Clinical Investigation	2004
Foxo1 Mediates Insulin Action on ApoC-III and Triglyceride Metabolism Jennifer Altomonte, Lin Cong, Sonal Harbaran, Anja Richter, Jing Xu, Marcia Meseck, Domenico Accili, Hengjiang Dong	Journal of Clinical Investigation	2004
New Insights into the Integrated Physiology of Insulin Action Y Kitamura, D Accili	Reviews in Endocrine and Metabolic Disorders	2004
Transcriptional networks controlling pancreatic development and beta cell function JM Servitja, J Ferrer	Diabetologia	2004
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation LP van der Heide, MF Hoekman, MP Smidt	Biochemical Journal	2004
Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification T Hosaka, WH 3rd, D Tieu, AD Boyer, NM Varki, WK Cavenee, KC Arden	Proceedings of the National Academy of Sciences	2004
Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms X Zhao, L Gan, H Pan, D Kan, M Majeski, SA Adam, TG Unterman	Biochemical Journal	2004
The role of Foxa-2 in adipocyte metabolism and differentiation Christian Wolfrum, David Q. Shih, Satoru Kuwajima, Andrew Norris, C. Ronald Kahn and Markus Stoffel	Journal of Clinical Investigation	2003
Up-regulation of insulin receptor substrate-2 in pancreatic beta-cells prevents diabetes Anita M. Hennige, Deborah J. Burks, Umut Ozcan, Rohit N. Kulkarni, Jing Ye, Sunmin Park, Markus Schubert, Tracey L. Fisher, Matt A. Dow, Rebecca Leshan, Mark Zakaria, Mahmud Mossa-Basha, Morris F. White	Journal of Clinical Investigation	2003
Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors ML Hribal, J Nakae, T Kitamura, JR Shutter, D Accili	The Journal of Cell Biology	2003

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