Androgenic Hormones Modulate Autoantibody Responses and Improve Survival in Murine Lupus

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Abstract

Antibodies to native DNA and to polyadenylic acid (Poly A) occur spontaneously and undergo a regulated switch from IgM to IgG during the course of autoimmune disease in NZB/NZW F1 (B/W) mice. B/W females have higher titers and earlier commitment to 7S antibodies to DNA and Poly A, whereas B/W males bind DNA and Poly A primarily by 19S antibodies. We have performed castration experiments to determine the effects of sex hormones on this switch from IgM to IgG.

Authors

Jirayr R. Roubinian, Ruben Papoian, Norman Talal