Dependence of Saline-Induced Natriuresis upon Exposure of the Kidney to the Physical Effects of Extracellular Fluid Volume Expansion

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Abstract

In many previous studies, the natriuresis induced by saline loading has been demonstrated to persist even though glomerular filtration rate (GFR) has been decreased to below pre-expansion levels by a reduction in renal artery pressure. In such studies, however, the kidney has been exposed to the effects of volume expansion for varying periods of time before renal artery pressure was controlled. The present experiments were designed to evaluate whether this period of exposure induces critical changes in intrarenal factors that are responsible for the natriuresis.

Authors

John P. Fitzgibbons, F. John Gennari, Howard B. Garfinkel, Stanley Cortell