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Airway plumbing
John W. Hanrahan
John W. Hanrahan
Published May 15, 2000
Citation Information: J Clin Invest. 2000;105(10):1343-1344. https://doi.org/10.1172/JCI10088.
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Commentary

Airway plumbing

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Abstract

Authors

John W. Hanrahan

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Figure 1

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Proposed mechanism for feedback regulation of ASL volume. (a) Evaporatio...
Proposed mechanism for feedback regulation of ASL volume. (a) Evaporation reduces ASL volume, reduces the efficiency of mucociliary clearance, and increases ASL osmolality. (b) High osmotic permeability of the apical membrane allows water to be drawn into the ASL to restore osmolality and causes the cells to shrink. Shrinkage of surface columnar cells triggers release of vasodilator substances such as nitric oxide (NO), which increase fluid delivery by subepithelial microvasculature.

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