THE JOURNAL OF CLINICAL INVESTIGATION

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The JCI is the publication of the American Society for Clinical Investigation, an honor society of physician-scientists.

May 2008: View the entire issue

Cover story: Walking on AIRE
H&E-stained section of the thyroid gland. Individuals develop the autoimmune disease autoimmune polyglandular syndrome type 1 (APS 1) if both copies of their AIRE gene are mutated such that they make no functional AIRE protein. Many different mutations in the AIRE gene have been linked to APS1. Individuals with a mutation known as G228W in just one copy of their AIRE gene have been identified and shown to exhibit a different pattern of symptoms to individuals with APS1. Insights into the mechanisms, especially in the thymus, by which the G228W mutation causes autoimmunity have now been provided by Maureen Su and colleagues (page 1712).

Also inside:

Could PPAR-γ antagonists be used to treat AIDS?

Regulating the hypothalamic-pituitary-gonad axis

IFN-β can prevent autoimmune disease mediated by Th17 cells

PI3K signaling is essential for leptin to signal in the hypothalamus

Global Health

Series funded by an unrestricted educational grant from the Bill and Melinda Gates Foundation

Although advances in science and technology have resulted in substantial improvements in the health of individuals in the developed world, similar progress has not been observed for those living in the developing world. This Review Series focuses on the health conditions that affect people living in the developing world, and it highlights some of the areas that require attention if these conditions are either to be brought under control or eradicated.

Molecular Mechanisms of Stress

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p21^Cip1 modulates arterial wound repair through the stromal cell–derived factor-1/CXCR4 axis in mice

Michelle Olive, Jason A. Mellad, Leilani E. Beltran, Mingchao Ma, Thomas Cimato, Audrey C. Noguchi, Hong San, Richard Childs, Jason C. Kovacic, and Manfred Boehm

RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice

Sergio Vaira, Muhammad Alhawagri, Imani Anwisye, Hideki Kitaura, Roberta Faccio, and Deborah Veis Novack

Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome

Michael Brunner, Xuwen Peng, Gong Xin Liu, Xiao-Qin Ren, Ohad Ziv, Bum-Rak Choi, Rajesh Mathur, Mohammed Hajjiri, Katja E. Odening, Eric Steinberg, Eduardo J. Folco, Ekatherini Pringa, Jason Centracchio, Roland R. Macharzina, Tammy Donahay, Lorraine Schofield,Naveed Rana, Malcolm Kirk, Gary F. Mitchell, Athena Poppas, Manfred Zehender, and Gideon Koren

Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells

Hewang Li, Ines Armando, Peiying Yu, Crisanto Escano, Susette C. Mueller, Laureano Asico, Annabelle Pascua, Quansheng Lu, Xiaoyan Wang, Van Anthony M. Villar, John E. Jones, Zheng Wang, Ammasi Periasamy, Yuen-Sum Lau, Patricio Soares-da-Silva, Karen Creswell, Gaétan Guillemette, David R. Sibley, Gilbert Eisner, Robin A. Felder, and Pedro A. Jose

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1

Jun H. Park, Doris A. Stoffers, Robert D. Nicholls, and Rebecca A. Simmons

Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans

Hiroshi Watanabe, Tamara T. Koopmann, Solena Le Scouarnec, Tao Yang, Christiana R. Ingram, Jean-Jacques Schott, Sophie Demolombe, Vincent Probst, Frédéric Anselme, Denis Escande, Ans C.P. Wiesfeld, Arne Pfeufer, Stefan Kääb, H.-Erich Wichmann, Can Hasdemir, Yoshifusa Aizawa, Arthur A.M. Wilde, Dan M. Roden, and Connie R. Bezzina

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