In this episode, Jayme Locke and Maggie Jones-Carr explain the histologic outcomes of a series of brain-dead human recipients of a porcine kidney xenotransplant using exclusively FDA-approved medications, with and without anti-C5 monoclonal antibody.
In this episode, Shashwat Tripathi and Hinda Najem discuss how, using scRNA-seq, their analysis shows that CAFs, specifically the immune modulatory subtype, are increased in frequency as a function of glioma grade. Notably, collagen is a key ligand for the immune checkpoint LAIR-1. The study also characterizes which collagens are present in gliomas and their anatomical locations within the tumor microenvironment that can serve as a reference for the scientific community.
In this episode, Laszlo Farkas explains that the results of this study indicate that reduced endothelial expression of endolysosomal RAB7 causes dysregulation of autophagy, mitochondrial dysfunction and endothelial senescence, and induces spontaneous PH.
In this episode, Ushma Neill speaks with physician and geneticist Dr. Funmi Olopade. Dr. Olopade is the founding director of the Center for Clinical Cancer Genetics and Global Health at the University of Chicago. Olopade's research is focused on gaining a better understanding of the root causes and genomic basis of cancer in diverse populations. She is internationally renowned for her work in inherited cancer syndromes and for her clinical expertise in early detection and prevention of breast cancer in high-risk women.
In this episode, Yijuang Chern and Jian Jing Siew discuss the novel role of Gal3 in the regulation of extracellular vesicles, promotion of pathogenic tau fibrillation, and microglial activation.