STING-mediated antitumor immunity and CDK12/13 inactivation triggers

In this episode, Yi Bao explains the that the manuscript's findings establish STING activation as the key driver of T cell infiltration and the immune-hot tumor microenvironment in CDK12 mutant cancers, suggesting that dual CDK12/13 inhibitors and degraders activate anti-tumor immunity and potentiate responses to immunotherapies.

Spesolimab targets IL-36R to alleviate inflammation and reduce generalized pustular psoriasis flares

In this episode, James G. Kreuger explains that people with generalized pustular psoriasis experience underlying skin inflammation, even in the absence of flares. Spesolimab treatment helps control the inflammation and prevent future flares.

Cyclin D1 overexpression causes replication stress and repair pathway dependence

In this episode, Dr. Jithma Prasad Abeykoon, explains how Cyclin D1 overexpression causes DNA damage and forces cancer cells to depend on targetable repair pathways.

JCI’s Conversations with Giants in Medicine: Ending one conversation

In this final episode of the series, the Conversations with Giants in Medicine series comes to a close. The JCI is heading in a new direction with its video content, and Ushma Neill too will be heading in a different career direction that makes it hard to continue the series with the same care. As is often noted, “All good things must come to an end.” Please watch a supercut of the last question she asked each subject, “What other vocation could have kept you as motivated?”

Baricitinib rapidly treats lichen planus by suppressing cytotoxic CXCL13+CD8+ T cells.

In this episode, Aaron R. Mangold explains how lichen planus is treated by suppressing cytotoxic CXCL13+CD8+ T-cells using baricitinib.