Video abstracts
In this video collection, authors of findings published in The Journal of Clinical Investigation present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Video Abstracts Guidelines page.
In this episode, Yi Bao explains the that the manuscript's findings establish STING activation as the key driver of T cell infiltration and the immune-hot tumor microenvironment in CDK12 mutant cancers, suggesting that dual CDK12/13 inhibitors and degraders activate anti-tumor immunity and potentiate responses to immunotherapies.
Spesolimab targets IL-36R to alleviate inflammation and reduce generalized pustular psoriasis flares
In this episode, James G. Kreuger explains that people with generalized pustular psoriasis experience underlying skin inflammation, even in the absence of flares. Spesolimab treatment helps control the inflammation and prevent future flares.
In this episode, Dr. Jithma Prasad Abeykoon, explains how Cyclin D1 overexpression causes DNA damage and forces cancer cells to depend on targetable repair pathways.
In this episode, Aaron R. Mangold explains how lichen planus is treated by suppressing cytotoxic CXCL13+CD8+ T-cells using baricitinib.
In this video, DeLisa Fairweather, Aaron H. Abend, and Ingrid He explain that their paper estimates the prevalence of all autoimmune disease in the US, sex- and age-adjusted, with individual estimates for 105 autoimmune diseases.
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ISSN: 0021-9738 (print), 1558-8238 (online)