Targeted expression of a human pituitary tumor–derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis

Original citation: J Clin Invest. 2002;109(1):69–78. doi:10.1172/JCI14036.

Citation for this retraction: J Clin Invest. 2015;125(8):3303. doi:10.1172/JCI83399.

An investigation by the University Health Network recently found that portions of the RT-PCR gels shown in Figure 1, B (PGK-1 panel) and C (FGFR1 panel), are duplicated in this publication and in a subsequent publication (1). The samples were labeled differently in the panels, and the marker was shifted in Figure 1B. The corresponding author has indicated that other data from the initial screen of these samples support the conclusions made in the paper; however, the original data for the RT-PCR gels shown in Figure 1 are no longer available. The JCI’s policies prohibit data manipulation and data duplication. Therefore, the JCI is retracting this article. No issues have been raised in regard to any of the other data in this manuscript.

Gillian E. Wu has agreed with the journal’s decision to retract the paper. Sylvia Asa, Shereen Ezzat, and Lei Zheng dissent from the retraction. Coauthor Xian-Feng Zhu could not be reached.

Footnotes

See the related article beginning on page 69.

References

1. Ezzat S, Yu S, Asa SL. Ikaros isoforms in human pituitary tumors: distinct localization, histone acetylation, and activation of the 5′ fibroblast growth factor receptor-4 promoter. Am J Pathol. 2003;163(3):1177–1184.
   View this article via: PubMed CrossRef Google Scholar