Molecular targets for tendon neoformation
Hadi Aslan, … , Gadi Pelled, Dan Gazit
Hadi Aslan, … , Gadi Pelled, Dan Gazit
Published February 1, 2008
Citation Information: J Clin Invest. 2008;118(2):439-444. https://doi.org/10.1172/JCI33944.
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Molecular targets for tendon neoformation

Abstract

Tendons and ligaments are unique forms of connective tissue that are considered an integral part of the musculoskeletal system. The ultimate function of tendon is to connect muscles to bones and to conduct the forces generated by muscle contraction into movements of the joints, whereas ligaments connect bone to bone and provide joint stabilization. Unfortunately, the almost acellular and collagen I–rich structure of tendons and ligaments makes them very poorly regenerating tissues. Injured tendons and ligaments are considered a major clinical challenge in orthopedic and sports medicine. This Review discusses the several factors that might serve as molecular targets that upon activation can enhance or lead to tendon neoformation.

Authors

Hadi Aslan, Nadav Kimelman-Bleich, Gadi Pelled, Dan Gazit

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Figure 1

Tendon structure and composition.

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Tendon structure and composition. The structure of tendons is organized ...
The structure of tendons is organized such that they provide resistance against the longitudinal stress generated by muscles. Chains of tropocollagen are longitudinally arranged and united into fibers that together form fibrils. Fibrils are organized and held in a linear direction by loose connective tissue called the endotenon such that they form fascicles. Fascicles are also packed by a loose connective tissue continuous with the endotenon that is called epitenon. The epitenon holds the structure of the tendon and provides its microvasculature. Reproduced from ref. 49.