Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent
J. Clin. Invest. Benyue Zhang, et al. 117:3029 doi:10.1172/JCI32426 [Go to this article.]

Figure 5
Kinetics of anti-CD137–induced immune suppression. Groups of C57BL/6 mice (n = 5) were infected i.p. with 2 × 10⁵ PFU LCMV Armstrong. One group of mice was then injected once with anti-CD137 i.p. 24 hours P.I. A second group was injected 1 day later and so on through day 5 P.I. On day 8 P.I. all groups were euthanized. (A) The percentage of GP33-41 tetramer–positive CD8⁺ splenic T cells was determined by FACS analysis. (B) Following in vitro GP33-41 peptide restimulation for 5 hours, the percentage of IFN-γ–producing CD8⁺ T cells was measured by ICS and FACS analysis. Untr, untreated.