Reversal of experimental pulmonary hypertension by PDGF inhibition
J. Clin. Invest. Ralph Theo Schermuly, et al. 115:2811 doi:10.1172/JCI24838 [
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Figure 3Effects of STI571 on the degree of muscularization (
A–
C), medial wall thickness of small pulmonary arteries (
D–
F), and PDGF-B expression (
G–
I).
A,
D, and
G: Day 0.
B,
E, and
H: Day 42.
C,
F, and
I: Day 42 treated with 50 mg/kg/d STI571. (
A–
C) The degree of muscularization is demonstrated by von Willebrand (brown) and α–smooth muscle actin (purple) staining for identifying endothelium and vascular SMCs, respectively. (
D–
F) Changes in medial wall thickness in pulmonary arteries are demonstrated. (
G–
I) PDGF-B staining is demonstrated in the medial layer of small pulmonary arteries. Scale bars: 20 μm. The arrows indicate pulmonary arteries.
