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East meets West: an herbal tea finds a receptor
Mitchell A. Lazar
Division of Endocrinology, Diabetes, and Metabolism, Departments of Medicine and Genetics, and the Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
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Published January 1, 2004 - More info
J Clin Invest. 2004;113(1):23–25. https://doi.org/10.1172/JCI20661.
© 2004 The American Society for Clinical Investigation
Advances in Western medicine have dramatically increased health and life expectancy (1). Nevertheless, over $4 billion is spent per year on herbal remedies that are complementary or alternative to Western-style care (2). Prescription medicines are usually purified molecules whose biological target is established and whose efficacy is endorsed by regulatory agencies. By contrast, herbal medicines often contain many ingredients whose effects on biochemical pathways are unknown and whose efficacy is unproven in controlled studies. A report in the current issue of the JCI helps to bridge this gap. David Moore and colleagues (3) show the improvement of jaundice by a Chinese herbal tea called Yin Zhi Huang (YZH), “boiled down” to one component that regulates the activity of a nuclear receptor previously implicated in bilirubin clearance (4, 5). This discovery provides a mechanistic rationale for pursuing an ingredient in YZH as a lead to improve upon the standard Western treatment for fetal jaundice.
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Nuclear receptors as targets of herbal remedies
Holistic medicine holds that herbal remedies work better when the whole complex of plant phytochemicals is kept together than when these chemicals are purified and administered singly or in combination. This hypothesis is difficult to put to stringent experimental test and remains a divisive point between Eastern and Western approaches. On the other hand, investigation of herbal remedies has revealed individual components that target nearly all classes of signaling molecules. For mechanism-based scientists and physicians, including myself (and presumably much of the JCI readership), it is both satisfying and reassuring when a single component of an herbal remedy turns out to function via a defined mechanism. Members of the nuclear receptor superfamily of ligand-regulated transcription factors are frequent biological targets of active compounds contained in herbal remedies. This is perhaps not surprising, since nuclear receptors evolved to be regulated by lipophilic molecules derived from diet and the environment (7, 8).
There are 48 nuclear receptors, some of which are “orphans,” meaning that no endogenous ligand has yet been found (9). At least ten of these receptors have been shown to be directly activated by compounds purified from herbal remedies (Table 1). Some compounds have a complex pharmacology; for example, grapeseed-derived resveratrol is an estrogen receptor ligand (10) but has also been suggested to activate a histone deacetylase enzyme implicated in the biology of aging (11). Other phytochemicals target multiple nuclear receptors (see Table 1 for examples). The pharmaceutical industry is now exploiting similar, less specific compounds, such as antidiabetic drugs that activate both PPARα and PPARγ (12). Indeed, although purified hormones have mostly replaced glandular extracts in Western medicine (13), a natural extract of pregnant mare’s urine containing at least ten estrogenic compounds is a widely prescribed treatment for menopausal symptoms (14).
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When things are investigated, then true knowledge is achieved. —Confucius
Neonatal jaundice is extremely common and may lead to neurotoxicity (15). The treatment of choice for this condition in Western medicine is ultraviolet light therapy; pharmaceutical treatments have not been popular. Two groups have recently noted that the nuclear receptor constitutive androstane receptor (CAR) enhances bilirubin clearance (3, 4). In the present issue of the JCI, noting that Chinese medicine uses YZH and a tea called Yin Chin for the treatment of jaundice, Huang et al. test the hypothesis that the Chinese remedies exert their effects via this mechanism (3). YZH and Yin Chin were obtained not from a chemical supplier but from a Chinese-herb store, were prepared as teas, and then were administered to mice (Figure 1). The herbal teas accelerated the clearance of bilirubin in normal mice, but not in mice that had been genetically engineered to lack CAR, demonstrating a critical role for this nuclear receptor. But that is only half of the story — the teas contain many ingredients, including one component (Scutellaria) that has been shown to contain an androgen receptor ligand (Table 1). However, the systematic study by Huang et al. reveals that a single compound found in both YZH and Yin Chin (6,7-dimethylesculetin) is sufficient to activate CAR and induce bilirubin clearance. This is a wonderful example of knowledge gained by applying the Western scientific method to an Eastern herbal remedy. It will be very exciting if a pure compound emerges from the tea leaves as a pharmacological therapy for neonatal jaundice that is complementary or alternative to the current Western practice of phototherapy (16).
Figure 1Eastern and Western paths to medicine. 6,7-Dimethylesculetin, in a wormwood tea or as a purified chemical, binds to and activates the hepatic nuclear receptor CAR and its target genes including CYP 2B10, leading to increased bilirubin clearance. Brewing of wormwood yields a tea that contains other chemicals, with potential for additional benefit or toxicity, or both.
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response to McDonagh
David M. Moore -
Herbal treatment of jaundice — risks.
Antony F. McDonagh -
Jaundice treatment
Howard W Chilton
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