The endogenous cannabinoid system protects against colonic inflammation
J. Clin. Invest. Federico Massa, et al. 113:1202 doi:10.1172/JCI19465 [Go to this article.]

Figure 4
Relative numbers of CB1- and Enk-expressing myenteric neurons are increased 3 days after DNBS treatment, as detected by ISH. (A and B) Micrographs showing CB1 mRNA in untreated (A) and in DNBS-treated (B) CB1^+/+ mice. (C) Quantitative evaluation of CB1-expressing cells in the myenteric plexuses of DNBS-treated CB1^+/+ mice (white bar, n = 3). (D–G) Micrographs showing Enk mRNA in untreated CB1^+/+ (D), untreated CB1^–/– (E), DNBS-treated CB1^+/+ (F), and DNBS-treated CB1^–/– (G) colons. (H) Quantitative evaluation of Enk-expressing cells in the myenteric plexuses of DNBS-treated CB1^+/+ (white bar, n = 3) and CB1^–/– (black bar, n = 3) mice. Values are means ± SEM. *P < 0.05, **P < 0.01 vs. respective untreated controls. Dotted lines, 100%. n = 3 per group. Arrows: CB1- and Enk-expressing cells. Scale bar: 100 μm.