Angiotensin II–accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice
J. Clin. Invest. Dennis Bruemmer, et al. 112:1318 doi:10.1172/JCI18141 [Go to this article.]

Figure 1
Ang II–accelerated atherosclerosis in male ApoE^–/–OPN^+/+, ApoE^–/–OPN^+/–, and ApoE^–/–OPN^–/– OPN mice. Three-month-old mice on a regular chow diet were infused with vehicle or Ang II for 4 weeks. (a) En face analysis of aortae stained with Sudan IV to visualize accumulation of subintimal lipids present in atherosclerotic lesions. (b) Mean atherosclerotic lesion areas of the thoracic aorta from ApoE^–/–OPN^+/+ wild-type mice (black bars), ApoE^–/–OPN^+/– (gray bars), and ApoE^–/–OPN^–/– (white bars) mice determined by computer-assisted image analysis. Data are represented as average percentage of the total surface of the thoracic aorta and expressed as mean ± SEM. *P < 0.05 vs. ApoE^–/–OPN^+/+ infused with Ang II.