The intricate interplay among body weight, stress, and the immune response to friend or foe
Lawrence Steinman, … , Rich Maki, Alan Foster
Lawrence Steinman, … , Rich Maki, Alan Foster
Published January 15, 2003
Citation Information: J Clin Invest. 2003;111(2):183-185. https://doi.org/10.1172/JCI17622.
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Commentary

The intricate interplay among body weight, stress, and the immune response to friend or foe

Abstract

Authors

Lawrence Steinman, Paul Conlon, Rich Maki, Alan Foster

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Figure 1

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Body fat and the autoimmune response. Decreases in body fat or starvatio...
Body fat and the autoimmune response. Decreases in body fat or starvation increase CRF levels and decrease leptin levels. Increased CRF downregulates Th1 immunity (5) as does decreased leptin (4). Other molecules of the α-MSH family stimulate Th1 T cells via their MC-4 receptor. CRFR, CRF receptor; LepR, leptin receptor.