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ResearchIn-Press PreviewCell biologyInflammation
Open Access | 
10.1172/JCI173994
NEDD4L mediates intestinal epithelial cell ferroptosis to restrict inflammatory bowel diseases and colorectal tumorigenesis
Jingjing Liang,1 Ning Wang,1 Yihan Yao,1 Yingmei Wang,2 Xiang An,1 Haofei Wang,1 Huan Liu,3 Yu Jiang,4 Hui Li,5 Xiaoqing Cheng,6 Jiaqi Xu,6 Xiaojing Liang,7 Jun Lou,7 Zengfeng Xin,1 Ting Zhang,8 Xiaojian Wang,1 and Wenlong Lin1
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Liang, J. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Wang, N. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Yao, Y. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Wang, Y. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by An, X. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Wang, H. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Liu, H. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Jiang, Y. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Li, H. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Cheng, X. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Xu, J. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Liang, X. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Lou, J. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Xin, Z. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Zhang, T. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Find articles by Wang, X. in: JCI | PubMed | Google Scholar
1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi’an, China
3Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
4Department of Clinical Laboratory Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
5Department of Medical Oncology, the Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China
6Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
7Department of Respiratory and Critical Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China
8Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Published December 17, 2024 - More info
Copyright © 2024, Liang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2024 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)