Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy
J. Clin. Invest. Nigel A. Calcutt, et al. 111:507 doi:10.1172/JCI15792 [
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Figure 3SHh-IgG treatment reverses conduction slowing in diabetic rats. MNCV (
a) and SNCV (
b) measurements were made in the same animals before the onset of diabetes, after 5 weeks of untreated diabetes, and after 5 weeks of thrice weekly treatment with 1 mg/kg of SHh-IgG or vehicle. Data are given as means ± SEM;
n = 10–12 per group. Vehicle-treated controls are represented by filled squares, SHh-IgG–treated controls by open squares, vehicle-treated diabetics by filled circles, and SHh-IgG–treated diabetics by open circles. Statistical comparisons between groups were made at the 10-week time point by ANOVA followed by the Student-Newman-Keuls post hoc test. *
P < 0.01 for untreated diabetics versus all other groups.
