Tangier disease as a test of the reverse cholesterol transport hypothesis
Alan R. Tall, Nan Wang
Alan R. Tall, Nan Wang
Published November 15, 2000
Citation Information: J Clin Invest. 2000;106(10):1205-1207. https://doi.org/10.1172/JCI11538.
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Figure 1

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HDL-mediated RCT. ABCA1 is involved in transfer of free cholesterol (FC)...
HDL-mediated RCT. ABCA1 is involved in transfer of free cholesterol (FC) and phospholipids (PL) from macrophages to apoA-I. Lecithin cholesterol acyltransferase (LCAT) converts FC to CE. CETP and PLTP modify HDL by transferring CE and PL between HDL and triglyceride-rich lipoproteins. HDL delivers cholesterol to liver via SR-BI–mediated selective uptake of the lipids.