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Research Article Free access | 10.1172/JCI113276

Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis.

D G Harrison, M L Armstrong, P C Freiman, and D D Heistad

Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242.

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Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242.

Find articles by Armstrong, M. in: JCI | PubMed | Google Scholar

Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242.

Find articles by Freiman, P. in: JCI | PubMed | Google Scholar

Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242.

Find articles by Heistad, D. in: JCI | PubMed | Google Scholar

Published December 1, 1987 - More info

Published in Volume 80, Issue 6 on December 1, 1987
J Clin Invest. 1987;80(6):1808–1811. https://doi.org/10.1172/JCI113276.
© 1987 The American Society for Clinical Investigation
Published December 1, 1987 - Version history
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Abstract

Atherosclerosis results in impaired relaxation to acetylcholine, thrombin, and the calcium ionophore A23187, all agents that require the presence of endothelium. We now report that dietary treatment of atherosclerosis in monkeys not only produces morphological improvement of the atherosclerotic lesion but restores endothelium-dependent vascular relaxation to normal. Because the intima remains thickened after regression of atherosclerosis, these studies suggest that intimal thickening which is present in both atherosclerotic vessels and after regression of atherosclerosis does not prevent the endothelium-derived relaxing factor from reaching the underlying vascular smooth muscle.

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