IL-22 is required for Th17 cell–mediated pathology in a mouse model of psoriasis-like skin inflammation
J. Clin. Invest. Hak-Ling Ma, et al. 118:597 doi:10.1172/JCI33263 [Go to this article.]

Figure 1
Coadministration of IL-12 and LPS enhances the development of skin lesions in a CD4⁺CD45RB^hi adoptive transfer model. (A) Disease progression in CB17 scid/scid recipient mice with or without (naive) adoptive transfer of 4 × 10⁵ CD4⁺CD45RB^hi sorted cells. The recipient mice with cell transfer were treated with saline or IL-12 (10 ng) plus LPS (20 μg) (i.p.) on day 1 and saline or IL-12 (10 ng) on day 3 (i.p.). *P < 0.05 starting from day 37 between the saline-treated group and the IL-12/LPS–treated group, both with cell transfer. (B) RNA was purified from an ear biopsy of each mouse within a group at the end of the study and evaluated by quantitative RT-PCR for the indicated cytokines. Results are reported as group means ± SEM, with n = 10 for each group. Data are representative of at least 2 independent experiments. *P < 0.05 between no-treatment group (naive) and saline-treated group with cell transfer; **P < 0.05 between no-treatment group (naive) and LPS plus IL-12–treated group with cell transfer; ***P value between saline and LPS plus IL-12 treated group is indicated.