Type I IFN innate immune response to adenovirus-mediated IFN-γ gene transfer contributes to the regression of cutaneous lymphomas
J. Clin. Invest. Mirjana Urosevic, et al. 117:2834 doi:10.1172/JCI32077 [
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Figure 6Expression of the genes involved in innate immune response to adenoviral vectors. (
A–
C) Expression of the genes involved in type I and II IFN signaling that have value in prediction of OR. The left panel shows a box plot that represents the summarized expression of the respective gene in baseline and posttreatment 3 samples (
y axis) normalized to CD4 and are grouped with respect to OR (
x axis). Right panel represents the ROC curve generated for the expression of the respective gene at posttreatment 3. For each gene, the
P value of area under the curve statistic is shown in parentheses. (
D) IL-6 concentration in patients’ sera. Values are summarized and shown as box plots that represent serum IL-6 values as pg/ml (
y axis) and are grouped according to status of the OR (
x axis). For a description of the box plot parameters, see Figure
4.
