Role of A_2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury
J. Clin. Invest. Chun-Xiao Sun, et al. 116:2173 doi:10.1172/JCI27303 [Go to this article.]

Figure 5
CVT-6883 treatment inhibits alveolar airway enlargement inADA^–/– mice. Lungs from postnatal day 38 mice were infused with fixative under constant pressure (25 cm H₂O) and processed for H&E staining. (A) Lung from an ADA⁺ mouse treated with vehicle. (B) Lung from an ADA⁺ mouse treated with CVT-6883. (C) Lung from an ADA^–/– mouse treated with vehicle. (D) Lung from an ADA^–/– mouse treated with CVT-6883. Images are representative of 8 animals from each group. Scale bars: 100 μm. (E) Alveolar airspace size was calculated using ImagePro analysis software; data are mean chord length ± SEM. *P ≤ 0.05 versus vehicle-treated ADA⁺ mice; ^#P ≤ 0.05 versus vehicle-treated ADA^–/– mice. n = 5 per group.