Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors
J. Clin. Invest. Masao Kakoki, et al. 116:1302 doi:10.1172/JCI26958 [Go to this article.]

Figure 6
Oxidative stress in vitro. (A) Mitochondrial oxidation (assessed by MitoTracker Red CM-H₂XRos fluorescence) in EA.hy926 vascular endothelial cells cultured in the presence of normal glucose (NG), high glucose (HG), HG plus 1 μM bradykinin (BK), or HG plus BK plus 1 mM l-NAME. BK reduced the oxidative signal seen in HG; this reduction was largely abolished by the NOS inhibitor l-NAME. Scale bars: 100 μm. (B) Quantitative analysis of MitoTracker Red fluorescence from single cells under the 4 culture conditions used in A. The data are means ± SEM with the numbers of cells shown in white digits.