Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors
J. Clin. Invest. Masao Kakoki, et al. 116:1302 doi:10.1172/JCI26958 [Go to this article.]

Figure 5
Alterations in mtDNA in 12-month-old mice of the 4 genotypes. (A) 8-OHdG content in renal cortical mtDNA. (B) Frequencies of point mutations in the cytochrome b gene in the mtDNA used in A. (C) Relative proportion of D-17 deletions (as percentage of WT) in the same DNA, determined by quantitative PCR. Data are presented as means ± SEM with the numbers of animals shown in white digits (see Supplemental Table 4 for 2-factor ANOVA analysis).